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In this article, we introduce a screening strategy that takes advantage of both the robustness of protein NMR spectroscopy as the detection method, and the basic principles of combinatorial chemistry to enable the screening of large libraries of fragments (>105 compounds) preassembled on a common backbone.
Also, the resulting scaffolds are already preassembled on a common backbone and thus will not require extensive medicinal chemistry expertise to obtain properly linked compounds.
This enabled us to define at least 8 different plasmids according to the placement of the contigs on a common backbone.
Randomizing more than 600 patients 1 1 to either CsA or Tac on a common backbone of basiliximab induction, MPA and prednisone provided an unprecedented large sample size associating CsA-MPA with a significantly lower rate of viremia than Tac-MPA, both at month 6 (10.6% vs. 16.3%, p = 0.048) and at month 12 (4.8% vs. 12.1%, p = 0.004).
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It has provided a common backbone for multiple data rates to coexist on same fiber along with the enhanced transmission reach.
These links form a common "backbone" to the protein.
The two strains share more than 4,000 genes, or what Dr. Frederick R. Blattner, the director of the Genome Center of Wisconsin, calls a common "backbone".
The core 9-mer peptide segment contacting the MHC assumes a common backbone conformation due to conserved hydrogen bonds to backbone atoms along its entire length.
These pXO2-like plasmids share a common backbone including genes involved in replication and putative conjugative functions.
The radial-backbone (or X-tree) structure is composed of two types of lines: the primary lines that travel exclusively on the common backbone (main corridor) and radial lines which, starting from the common backbone, branch out to individual locations.
Four molecular electron acceptors based on a common phthalimide end-capped diketopyrrolopyrrole π-conjugated backbone, solubilized by different alkyl groups, have been synthesized.
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