The example of the development of solar technology in Germany has amply shown that the initiative for experimenting with and developing this technology came from certain local and/or regional pockets in opposition to developments on a more central level, be it the federal or state government or the incumbent actors in the field of electricity supply [[7]].
Although it is well-documented that RA patients have lower pain thresholds than healthy controls [ 6, 10- 16], little is known about the factors associated with low pain thresholds and whether these factors impact pain thresholds on a peripheral, local level (i.e. at the joints) or on a central, widespread level.
However, the large complexity of the signalling network controlling integrity of the organism has made studies on the pathophysiology of, for example, the anorexia-cachexia syndrome on the central level a difficult task.
The WHO Coordinating Unit and the centres will decide whether online data entry will take place at the facility or at a more central level depending on the resources available in each centre.
Due to a generally weak State presence in the provinces, UNICEF's work with the Government has been focused on central level.
According to the Swedish National Insurance Act the social insurance office has to cooperate with the health services, the employers and other important actors in the rehabilitation process on a local, regional and central level, to support the individual needs of the patient [ 9, 10].
Therefore, it can be hypothesized that a direct effect on TG or at central level may occur as well as an indirect activation via exposed keratinocytes or other cells in the nerve endings proximity.
In Tanzania, the Ministry of Health and Social Welfare implemented the FANC policy in 2002 and used it for cascading health worker training on a central, regional and district level [ 11, 12].
The budget spent on capacity building at central level.
Thus, it seems that a cross-talk between BMP signals and SNS activation on peripheral and central levels may be a critical way to modulate global thermogenic capacity.
