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We appraised the results of the studies by examining the relation established between the costs and consequences; the alternative interventions that were considered; the costs and consequences that were included or omitted; the study limitations; and potential conflicts of interests.
When we omitted the study of Welzel et al. [ 7] from the meta-analysis for choledocholithiasis, the outcome still remained statistically significant.
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For the sake of conciseness, we omit the study of this latter situation, which is beyond the goal of the present paper.
Omitting the study of Kristensen et al. [13], there were 12 comparisons that associate organismal traits with gene expression in inbred lines [4] and Ayroles et al. [14] with 10 significant overlaps, and 10 comparisons between the remaining studies [1], [5], [6] and Ayroles et al. [14] with 3 significant comparisons.
The heterogeneity was explained by the influence analysis omitting the study by Thornton et al.[ 26], which showed an increased risk of cesarean section among the intervention group.
The heterogeneity was explained by the influence analysis omitting the study by Badrawi et al [ 37], which involved a balanced low-energy diet (1500-2000 Kcal/day).
The summary RR of RA risk per 5 kg/m increase in BMI did not significantly change after one study at a time was removed; for example, it was 1.01 (1.00 to 1.03; P = 0.058) after omitting the NHS2 cohort study of Lu et al., and 1.03 (1.01 to 1.06) after omitting the study of Wesley et al. [ 14, 27].
A statistically nonsignificant reduction in the risk of non-Hodgkin lymphoma was observed in statin users omitting the studies of Fortuny et al.
The results from the pooled ORs before and after omitting the studies that deviated from the studies that used the HWE principles were similar, suggesting that the results were minimally affected by this study.
The effect estimate became larger after we omitted the influential study by Payen (RR, 1.76, 95% CI, 1.05 to 2.93, P = 0.03, I = 0%).
Thus, omitting the rest study if the stress study is normal is a safe procedure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com