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On day 22, both drugs were omitted in two patients in DL 3, due to grade 3 neutropenia and persistent chest infection, respectively.
Response assessment was omitted in two patients after achieving complete response (CR) during early response evaluation since these patients did not have any detectable clinical evidence of disease and disease-related symptoms.
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Consolidation therapy with TAD was administered in 36 of the 43 (84 %) living patients and omitted in seven cases (16 %) due to severe side effects during induction.
The day-8 dose of gemcitabine was omitted in eight cycles (7%) in six patients, and reduced in six cycles (5%) in five patients, with a 50% reduction in two cycles and a 75% reduction in four cycles.
The planned day 15 Cisplatin treatment was omitted in six patients due to the following reasons: grade 4 neutropenia in five twoo in DL 4 and three in DL 3) and chest infection in one patient (DL 3).
One and two doses of irinotecan had to be omitted in nine (24%) and three (8%) patients, respectively, in three cases because of leukopenia grade 3 and 4, in three cases because of fever, and in six cases because of diarrhoea grade 3 and 4. Acute cholinergic symptoms including acute diarrhoea were not encountered, and premedication with atropin was not required.
His proposal to force greater disclosure failed by a 42-52 vote, and thus was omitted in the five year extension of the FISA Amendment Act President Obama signed on Dec. 30.
Deinstitutionalisation is omitted in all four policies.
The two extra visits required for objective assessment of PA and accurate evaluation of diet have been omitted in all but two sites (as planned) and dietary assessment reduced to a validated FFQ.
Given the good penetrance of systemic methotrexate into the CSF and the potentially increased risk for leukoencephalopathy with additional intrathecal methotrexate, intrathecal methotrexate was omitted in the last three patients of the series.
The final passage in Mark (16:9–20) is omitted in some manuscripts, including the two oldest, and a shorter passage is substituted in others.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com