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As highlighted by Shih et al and mentioned within current Canadian guidelines, 2, 4 when both drugs are patented drugs, ICER will likely be underestimated if economic evaluations omit the potential future introduction of lower-cost generic versions.
However, within economic evaluations comparing a new patented drug to a generic comparator drug which omit the potential future introduction of lower-cost generic versions of the new drug, the ICER will likely be overestimated.
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Significantly, this omits the potential impacts of providing informal care to patients that may not have resulted in time lost from work (e.g. negative impact on the health and well-being of caregivers).
In order to omit this potential limitation, Chen and colleagues examined a modified version of AQ20, but did not observe a significant impact in its performance [ 23].
(I omit the dancers).
We omit the proofs.
We omit the details.
We appraised the results of the studies by examining the relation established between the costs and consequences; the alternative interventions that were considered; the costs and consequences that were included or omitted; the study limitations; and potential conflicts of interests.
The exclusion of rRNA and tRNA was also omitted, to avoid the potential loss of other RNA species.
4 These graphs are obtained by omitting the United States and Brazil from the list of potential destinations.
Many energy security analyses omit potential future changes in the energy mix, the implications that a growing uptake of renewable energy could have [14, 15], and the influence of broader societal transformations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com