Using anti-GFP staining, we identified putative sphinx expression signal in the brain antennal lobe and inner antennocerebral tract, suggesting that sphinx might be involved in olfactory neuron mediated regulation of male courtship behavior.
The only enriched GO function in the olfactory bulb is "regulation of cell cycle", which could be affected by processes that modulate the rate or extent of progression through the cell cycle.
According to the findings obtained using curated pathway gene sets, the pathway involved in olfactory signalling and regulation is the least conserved since it has significant features of divergence for three of the parameters considered, indicating an increased functionality in the mouse (Fig. 3, Additional file 5).
Previous work indicates that the rate of spontaneous reversals is regulated by food and olfactory cues, and this regulation is critical for successful foraging and chemoattraction [38] [40].
More recently, the function of PrPc in the regulation of olfactory behavior and dendrodendritic synaptic transmission in olfactory neurons has been described [17].
Herein we describe a role for the C. elegans D2-like receptor DOP-3 in the regulation of olfactory sensitivity.
The results provide insights into the functions of synaptic circuits in the intact olfactory bulb, including the regulation of the total output activity, the mechanisms of interneuron activation, and the oscillatory synchronization of neuronal ensembles.
We find that OSNs can act as differentiators that transiently normalize stimulus intensity a property potentially derived from a combination of integral feedback and feed-forward regulation of olfactory transduction.
As reported previously, levels of Orco in the chemosensory tissues of two Anophelinae mosquitoes were consistently close to one-to-one as compared with the sum total of all tuning ORs in anopheline antennae, suggesting a possible mechanism of Orco-OR complex regulation within olfactory receptor neurons (ORNs) (Pitts et al. 2011; Rinker, Pitts, et al. 2013; Rinker, Zhou, et al. 2013).
In summary, our results provide evidence that BMP signals affect neurogenesis in the olfactory epithelium in part via regulation of Notch activity.
