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Because the most frequent ND was impaired olfaction, we considered other causes of olfactory impairment: smoking, 29 upper respiratory infection 30 and nasal sinus disease.
These results show that the two strains of AD model mice do not display an olfactory impairment in a time course consistent with human AD, but are impaired in visuospatial capabilities.
About a quarter of adults, and more than half of those over 80, have some degree of olfactory impairment.
To investigate peripheral nasal pathology as a contributor to olfactory impairment in DS.
Despite its relatively high prevalence, population-based data are lacking on whether olfactory impairment influences the functional status and independence of older adults.
However, UPSIT scores were significantly worse in the DS patients, most of whom met criteria for a clinically meaningful olfactory impairment.
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Understanding the nature of these physiologic olfactory impairments could offer clues to the basic neuropathology of this disorder.
Our finding of a lack of systematic differences in olfactory performance between the two AD mouse model strains employed here and the control mice is in contrast with several studies that reported more or less pronounced olfactory impairments in other mouse strains with AD neuropathologies.
Olfactory impairments have been shown in an animal model with reduced monoaminergic storage capacity (Taylor et al., 2009).
Prior to testing of ASD-related behaviors, we first evaluated whether mutant mice had motor alterations, olfactory impairments or anxiety-related behaviors that may impact social behavior.
To rule out a role of olfactory impairments on social deficits, we performed the buried food olfactory test, by evaluating the olfactory ability of mice to find a buried piece of food.
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