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Results indicated that exposure to 56Fe particles can produce alterations in behavior and neuronal signaling and that these alterations may be more apparent in older organisms, a finding which suggests that the aging brain may be more susceptible to the deleterious effects of irradiation on performance.
Therefore, p53 regulation is another case of antagonistic pleiotropy, protective in the young but deleterious in older organisms.
Hence, cells in certain older organisms, including humans, have shorter telomeres on average than cells in younger organisms.
Thus, miR-34a's continuing rise in late life may cause a reduction of SIRT1, a loss ill afforded by older organisms [ 35- 37].
Thus, if aging alone can induce chromosome instability when eroded telomeres meet checkpoint impairments, radiation would exacerbate this scenario by further compromising genomic stability in older organisms.
Age-associated degenerative processes such as a decline in proteostatic capacity are not necessarily restricted to older organisms but can also be observed in young adults (Labbadia and Morimoto, 2015a; 2015a).
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Couldn't it perhaps Leap back into that older organism?
Therefore, the cellular composition is different between a young and an older organism that has been exposed to a multitude of antigens and developed an immune memory.
As Dictyostelium represents an evolutionary older organism than yeast, Frizzleds may be considered as archetypic receptors, suggesting that they may be compatible with the yeast GPCR- machinery.
It is therefore also conceivable that the recently identified Frizzled-like receptors in the genome of the evolutionary older organism Dictyostelium [13] function through a similar ancestral mechanism.
The three LytR-CpsA-Psr proteins common to staphylococci and listeria most likely were present in an evolutionary older organism before their phylogenetic separation, however, the cluster analysis leaves the phylogeny of the LytR-CpsA-Psr proteins in general open, and a hypothesis that cluster M represents the most original group remains speculative.
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