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The pilot study reported here explored the ability of a community-based PRT program to reduce depression in older depressed patients.
The study also aimed to determine whether PRT improves depressive status in older depressed patients.
For example, in a study of 101 older depressed psychiatric outpatients, those with anxious depression were more likely to discontinue treatment and to have an attenuated response to nortriptyline (Flint and Rifat 1997a).
Because aging is associated with decreased cardiac vagal activity, it is possible that autonomic abnormalities are even more pronounced in the older depressed patients.
The present study examined the effects that treatment (randomized double-blind design) with either an SSRI (paroxetine) or a tricyclic antidepressant (nortriptyline) had on cognition in older depressed patients.
These changes are primarily ischemic in origin [1], and although are observed in normal aging, are often more severe in older depressed individuals [2].
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As Reynolds et al. [ 25] note, the number and severity of co-morbid medical illnesses moderate depression recurrence in older old depressed patient.
In the only RCT involving older, mildly depressed diabetes patients, paroxetine demonstrated no statistically significant differences compared with placebo therapy regarding health related quality of life (HRQoL), glycaemic control, or symptoms of depression after six months [ 25].
Although the practice of including family members could introduce potential response biases, having family members serve as co-informants during research interviews may help older and/or depressed patients recall a large proportion of their earlier diagnosed conditions to improve reporting.
This study examined the associations between sociodemographic characteristics, psychiatric comorbidities, and medical comorbidities and the receipt of depression treatment among depressed older adults in the VA.
There is much about getting older that depresses her, she admits: she will never know how people will grow up or how certain world events will play out.
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