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A total of 40 adult male Swiss albino rats (Sprague dawley strain) (10 ± 2 weeks old: weighting 120 ± 10 g) purchased from the Egyptian Holding Company for Biological Products and Vaccines (Helwan, Cairo, Egypt) were used in the current study.
Male Sprague-Dawley rats (6-week old) weighting 160 180 g were provided by Guangdong Laboratory Animal Center.
Male C57BL/6 mice, 6 8 weeks old, weighting 20-25 g, were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, Shanghai, China.
Sprague-Dawley rats (half male and half female, 4 6 weeks old, weighting 230 ± 20 g) were obtained from the animal center of Nantong University (Jiangsu, China).
Male Wistar albino rats (12 to 13 weeks old) weighting 260 ± 10 g were received from Experimental Animal Care Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Three healthy laboratory beagles and two purpose-bred laboratory dogs (four males and one female, 4 to 8 years old, weighting 11 32 kg) from the veterinary faculty of Ghent were enrolled.
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