LRCHL is characterized by older age at presentation, infrequent mediastinal involvement, and excellent prognosis [ 2, 8, 11].
Type II endometrial cancers constitute the minority of cases, but are typified by an aggressive clinical course with a distinct pattern of metastasis, older age at presentation, the absence of antecedent history of unopposed estrogen, and serous, clear cell or grade 3 endometrioid histology [ 7, 8]; aneuploidy, mutations in p53, and Her2/Neu overexpression are common [ 9- 12].
However, when multivariate analyses are used, it is clear that some of the differences may well be related to older age at diagnosis and other adverse presentation features [ 34].
This is supported by a higher rate of positive family history of CD in patients with a younger age at diagnosis with respect to patients with older age at diagnosis, suggesting that an earlier presentation may be due to a higher burden of disease-causing mutations in the genomes of these affected children compared to those in whom disease manifests later in life [ 32].
Myeloma is a disease of older individuals, with median age at presentation of ~66 years.
It typically occurs in older girls with a mean age at presentation of 15 years.
AML generally affects older individuals with a median age at presentation of around 65 years in Western countries [ 11] and it accounts for ~ 29% of all leukemias in adults in US.
The median age at presentation was older among patients who were treated with alkylating agents (53.8 years) and dapsone (70.5 years), drugs that were often used for mucous membrane pemphigoid with ocular involvement (usually a disease of the elderly).
Median age at presentation was 76 71-800) years old.
TNBC are associated with a younger age at presentation, having a mean age of 53 years old, compared to 58 years old for other subgroups in a study reported by Dent and al [ 7].
RCC tends to affect an older age group than Wilms tumour with a mean age at presentation of 9 years.
