Labd-7,13-dien-15-ol (1), a major lipophilic constituent of the resin 'ladano' was found to exhibit cytotoxic and cytostatic activity against cell lines derived from solid tumors with a profound activity on small lung cancer cells, DMS114.
Two diacetylene molecules incorporating an ynamine moiety, 5- diphenylamino -2,4-pentadiyne-1-ol (1) and 6-(diphenylamino)-2-methylhexa-3,5- diphenylamino -2,4-pentadiyne-1-olaracterized by single crystal X-ray diffraction, 1H and 13C NMR.
Previously, we identified 1- 2- 4-bromophenoxy)ethoxy)-3-(4-(2-methoxyphenyl)piperazin-1- 2- 4-bromophenoxy as a novel Hsp90 inhibitor with moderate activity through virtual screening.
In particular, the compound 13, the conjugate of two molecules of 3α-methoxyserrat-14-en-21β-ol (1) and one molecule of kojic acid, exerted significant anti-HIV activity with an EC50 value of 0.12 μg/mL.
Trimethylamine (33% w/w solution in ethanol, excess 20 100 eq) was added to n-bromoalkan-1-ol (1 eq) and left for 24 h.
For optimization of the reaction conditions, 4-phenylbut-3-yn-2-ol (1 a) and thiophenol (2 a) were chosen as model substrates.
3-Methyl butan-1-ol (1 ml) was added to the mixture, vortex mixed and the organic layer was left to separate from the aqueous layer.
As shown in Figure 2, terpinen-4-ol (1% v/v) also caused a rapid clearance of the FLC-resistant strain from the vagina of experimentally infected rats.
Six cytotoxic constituents, namely, ergostadien-3-ol (1), ludartin (2), 5-hydroxy-6,7,3,4-tetramethoxyflavone (3) (from shoot) and trans-matricaria ester (4), diacetylenic spiroenol ether (5), and cis-matricaria ester (6) (from root), have been isolated [ 19].
Notable compounds of fuel interest included nonanal, 1-octen-3-ol, 1-butanol, 3-methyl and benzaldehyde.
For all mixes, a precursor octahedral layered K-birnessite (K-OL-1) was formed after 1 d that subsequently transformed into K-OMS-2.
