IO are often well tolerated; however, uncontrolled and unexpected off-target effects can occur, resulting in wide-ranging and varied toxicities.
One study showed that the herb can help people fall asleep, but participants in the trial didn't have MS. Plus, it comes with a caution: Though it is often well tolerated, valerian may affect some prescription MS medications by increasing their sedating effects.
Corticosteroids are often well tolerated; however, long-term corticosteroid treatment is associated with well-recognised side effects and complications, such as osteoporosis.
ZNS is often well tolerated, but some authors suggested that its use may be limited by somnolence, psychiatric, and cognitive adverse effects.
This position is often well tolerated by anxious patients, as they can see out of the magnet, but in severe cases a light sedative may be administered.
In such cases, prosthetic loading of atrophic mucosa is often not well tolerated.
11, 43 In humans, the quick increase in serotonin is often not well tolerated, especially due to gastrointestinal side effects.
Unfortunately, the combination in many children of both autistic spectrum disorders (in particular sensory sensitivities) and severe learning difficulties meant that actigraphy was often not well tolerated, and more watches were broken or lost than expected.
With the recent emergence of new antithrombotic drugs (i.e., dabigatran, rivaroxaban, apixaban, and edoxaban), it became clear that VKA, although being more effective than aspirin and combination aspirin-clopidogrel, is often not well tolerated by patients, has a very narrow therapeutic range, and has a high risk for bleeding complications.
Moreover, suggested first-line therapies are often not well tolerated, and may be contraindicated in some patients due to coexistent medical problems, especially in the elderly, as the majority of these patients have pre-existing conditions such as diabetes, renal, cardiovascular or gastrointestinal diseases [ 9, 2].
Unilateral division of the OB, which is often necessary for surgical exposure, is well tolerated by the patients because the olfactory function is preserved.
