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GntR family regulators often regulate (e.g. repress) the expression of neighbor genes [ 41] and the increased expression in R6Δspr0058 of adjacent genes spr0059-65 coding for sugar transporters and metabolizing enzymes is consistent with this assumption.
Members of the multiple antibiotic resistance regulator (MarR) family often regulate gene activity by responding to a specific ligand.
One of the origins of network structure is combinatorial regulation; i.e. single TFs often regulate more than one target, and particular targets are often regulated by more than one TF.
Besides the annotation of ncRNAs with known functions, we additionally aimed to detect novel ncRNAs, as they often regulate transcription or play an important role as posttranscriptional regulators.
The gene product of spr0058 has similarity with regulators of the metabolite-responsive GntR family, which often regulate the expression of genes nearby of their location on the chromosome [ 41].
As with their regulation of each other, it is likely that they also often regulate these downstream target genes in a coordinated manner [17].
Transcription factors often regulate the expression of different cytokines and are essential for the regulation of gene expression.
Single microRNAs, for example, often regulate the levels of hundreds of different proteins.
Institutionalized age markers, such as legal age, often regulate the timing of a transition.
Similar(2)
Functionally related genes that are involved in the same biological pathways are often regulated by similar gene regulators (16, 17).
Alternative exons are often regulated according to cell-specific patterns and regulation is mediated by specific sets of cis-acting elements and trans-acting factors.
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