For mild disease, less toxic but often less efficacious drugs are recommended, while on the other hand, more efficacious yet potentially more toxic drugs are typically administered to patients with severe disease or those who are not responsive to first-line therapy.
Complex interventions often prove efficacious in RCTs conducted in well-controlled circumstances, but less effective in practice [ 5, 6].
The heptapeptide SP1 7 amide (2, Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-NH2) is oftexperimentalcacious than 1 in expainmodels pain models.
Mucosal, as opposed to systemic vaccination is often more efficacious against mucosal pathogens due to their ability to induce secretory IgA [1], [2].
74 Targeted therapies directed at oncogene-addicted tumors often are efficacious for a limited period of time before the onset of acquired resistance.
However, despite their exquisite target selectivity, antibodies are often not efficacious enough to provide the desired therapeutic effect in isolation and are often prescribed in combination with a non-specific chemotherapy.
For example, for the large numbers of individuals suffering symptoms of irritable bowel syndrome (IBS) where conventional treatment is often poorly efficacious, the potential for alternative evidence based therapies is considerable.
This strategy is often effective in patients with less severe lung diseases, but is less efficacious in patients with ARDS with high shunt fractions [ 6].
Current therapies are only moderately efficacious, often coupled with adverse side effects.
Experience has shown us that stigma is resilient, being difficult to eradicate; anti-stigma initiatives are often less than efficacious, especially regarding stigma toward schizophrenia [ 13- 15].
