Yet Ras genes and Braf, while often activated in cancer cells, are infrequent targets for activation in neuroblastoma.
Chk1 and Chk2 are often activated by ATM and ATR, resulting in a cascade of activation of further downstream signals.
The TORC1 pathway is often activated in human cancers and rapamycin exhibits anti-tumorigenic activity (Guertin & Sabatini, 2007).
IP3Rs located at the surface of the ER are often activated via the production of phospholipase C PLCC) following the activation of group I mGluRs.
ERK1/2 is often activated by growth factors [12], while p38 and SAPK/JNK are stress-activated protein kinases, which respond to cellular stress and inflammatory cytokines [14, 15, 17].
Recent research has shown that when undecided voters looked at images of candidates, their brains' emotional centers were often activated.
This impulse to speak is important for it is often activated by a moral impulse to tell the truth and avoid the tyranny of silence.
As for books, children's titles are leading the way with apps that include animated illustrations, often activated by the reader.
Still, pink lips and a perky nose confirmed its presence, as did a quality of roguish animation, of uppity Irish egotism, that often activated the Cherokee mask, and took control completely when he played the guitar and sang.
They are often activated when the weight of an armored vehicle -- or sometimes just a soldier or a Marine walking overhead -- squeezes together a trigger consisting of two buried slats, which closes a circuit that detonates the bomb.
However, TGFβ signaling is often activated in tumor stroma.
