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The Gene Mine is a mouse reference population derived from eight genetically diverse founder strains, with the genome of each offspring strain being a mosaic of chromosomal segments inherited randomly from the founders.
Implantation of a female BDF1 mouse with genetically distinct (C57 and Agoutie) embryos produced highly similar GTM profiles (c. 95% concordance) between mother and offspring, regardless of offspring strain, which was also reflected in urinary metabolite profiles.
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The adaptive microevolution might lead to the discrete segregation between the progenitor and offspring strains.
This genome reduction gradually caused the offspring strains to inhabit a more specific host niche, without overlapping with their progenitors.
Our data demonstrate that expression of FLO1 may not be the biomarker for a clumping phenotype, although an unexpressed FLO1 allele from the non-clumpy strain, which is isogenic to S228C, may enhance clumping of its offspring strains carrying other major clumping genes.
Males were found at frequencies of 0.7 %, 1.2 % and 1.2%% (n = approximately 2,500 offspring per strain) among the progenies of females from the thelytokous strains SPP, HR and TK, respectively.
Transgenerational epigenetic inheritance mediated by sRNAs was recently reported from C. elegans, where it was shown that offspring of strains exposed to dsRNA had direct chromatin modifications at the target site and generated more sRNAs in subsequent generations.
The F1 offspring between GAL4 strain females and DSK001 males were used as a control.
The number of offspring that a strain with mean μ and variance σ produces (or leaves behind) after experiencing environment e is proportional to f (μ, σ | μ e, τ ).
The study may have significance far beyond Arabidopsis; Dr. Bomblies, who last year won a MacArthur Foundation fellowship for her research, notes that breeders have noticed the withering of different strains' offspring in a variety of species, including wheat, tobacco, cotton and the houseplant Streptocarpus.
The F1 offspring of both strains developed inflammation at both locations (B 't Hart, personal observation).
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