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The genome of a digital organism contains information for copying itself, such that execution of the instructions contained in the genome by a virtual CPU results in the production of an offspring program.
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Moderate caloric restriction in rats during the first half of gestation has been previously described to have lasting effect in the offspring, programming animals for greater food intake [6].
The resulting GM male mosquitoes are then released into the wild to breed with non-GM females, producing offspring genetically programmed to die well before reproductive age.
Other mechanisms, such as catecholamines (Harris and Seckl 2011), intrauterine artery resistance, and intrauterine perception and learning (Kinsella and Monk 2009), also may be involved in offspring disease programming.
When comparing to the above-mentioned studies, this is the first study to investigate whether FM supplementation during gestation and lactation can protect the offspring from programming following simulated maternal infection during late gestation.
There is also increasing evidence that maternal malnutrition and deranged metabolism could have detrimental effects on offspring ("fetal programming") and it is very likely that epigenomes are continuously shaped during lifetime exerting effects also on subsequent generations [ 12].
Among the offspring of that program were notable llamas like Dr. Doolittle, whose heavy white fleece produced 17 pounds of fiber when shorn and whose descendants are prizewinning llamas today.
Maternal pre-pregnancy overweight is known to program offspring for adverse health outcomes later in life.
Although maternal high fat diet (HFD) consumption during the perinatal period has been reported to program offspring behavior, the underlying mechanisms remain to be elucidated.
Because all mothers in ACHOIS had mild GDM, we could not assess the effect of treatment of more severe GDM, which might be necessary to program offspring obesity.
It is now accepted that intrauterine nutrition can program offspring metabolism, creating stable changes in physiology that may have significant health consequences.
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