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The premise of the current investigation was to offer a pipeline of computational methods in the format of PK/ePD models that offers a systems pharmacological approach to personalized and precision medicine.
Our results from a large multicenter study [ 93] (and manuscript in preparation) provide a proof of concept that, when combined with other informative clinical parameters, B-cell profiling offers a systems biology approach to identifying potential biomarkers for the diagnosis, prognosis and treatment monitoring of lupus disease.
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