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Some eligible participants are randomly selected to be offered an intervention.
Sensitivity, specificity, PPV and NPV were not reported, as women who were classified as at risk from this assessment were then offered an intervention.
Patients are first offered an intervention that, while likely to be effective, is relatively easy to implement and carries relatively low cost or side effects.
Its design does not comply with the classic RCT requirements in which participants are aware they may be offered an intervention or the placebo.
They will also be informed that only patients who are randomly selected to be offered an intervention will be contacted about the intervention.
In the cmRCT design, as described to patients when they consent to participate in the cohort, only eligible patients randomly selected to be offered an intervention, but not eligible non-selected patients, are contacted and offered treatment.
Similar(49)
If the desirable effects outweigh the undesirable effects, we recommend that clinicians offer an intervention to typical patients.
There are obvious technical considerations in preferring to offer an intervention to patients with fewer metastases.
We propose that promotion of autophagy and mitochondrial quality control may offer an intervention against age-related fibrotic diseases.
Studies that clearly define how they do what they do and why they are doing it are more likely to have results that satisfy a range of possible stakeholders than studies that offer an intervention that lacks model validity.
A minority of the children had low propensity (6.9%) and should initially be offered an alternative intervention with oral health education.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com