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If the desirable effects outweigh the undesirable effects, we recommend that clinicians offer an intervention to typical patients.
We did not do this in the current study as it was not deemed ethical for us to recruit at-risk children and not offer an intervention for 12 months.
There are obvious technical considerations in preferring to offer an intervention to patients with fewer metastases.
We propose that promotion of autophagy and mitochondrial quality control may offer an intervention against age-related fibrotic diseases.
Studies that clearly define how they do what they do and why they are doing it are more likely to have results that satisfy a range of possible stakeholders than studies that offer an intervention that lacks model validity.
The findings of the present study suggest that common multiple sex partners and existing sexual network among this group could offer an intervention opportunity to reduce HIV/AIDS-related stigmatizing and discriminatory attitudes and strengthen alcohol use prevention and risk reduction initiatives among MSM.
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Randomization of who is offered an intervention can be conducted on a set of potentially eligible individuals with a waiver of informed consent.
Some eligible participants are randomly selected to be offered an intervention.
They will also be informed that only patients who are randomly selected to be offered an intervention will be contacted about the intervention.
In the cmRCT design, however, randomisation occurs prior to offer of intervention, and some number of eligible patients who are randomly selected to be offered an intervention will not accept the offer.
Its design does not comply with the classic RCT requirements in which participants are aware they may be offered an intervention or the placebo.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com