Sentence examples for off-target interaction from inspiring English sources

Morpholinos have become a standard knockdown tool in animal embryonic systems, which have a broader range of gene expression than adult cells and can be strongly affected by an off-target interaction.

On the contrary, the unpredictable off-target interaction may also give rise to safety effects on patients.

This required that all 32 hypothetical off-target interactions within the eight-peptide interactome be disfavoured and that the four desired interactions pair correctly.

Here, we evaluated the potential for the IgG4-Fc linker to result in off-target interactions with Fc gamma receptors (FcγRs).

Unanticipated off-target interactions, including at biogenic amine receptors, were then modeled using a structure-based approach to provide a consistent understanding of recognition.

We show that the method generates binding surfaces that are more conformationally restricted than previous design methods, reducing opportunities for off-target interactions.

We have also made the choice to limit our analysis to targets with known pharmacological action, which means that we end up correlating phenotypes which may, in fact, be driven by off-target interactions with the genetics of known targets.

The method could help predict undesirable off-target interactions, suggest ways of regulating a drug's activity, and identify novel therapeutic uses for FDA-approved drugs, three critical challenges in drug development.

It might appear a promising way to raise signal; "however, it may also increase the signal rising from off-target interactions". Off-target signals might blend with the background noise, but once the off-targets become more prominent and resemble positive peaks, more antibody produces more false positives.

The microarrays revealed not only very detailed specificity profiles for all the binders, but also showed that overlapping target sequences of spotted antigens were detected by off-target interactions.

NanoRx offer the potential to solve many drug delivery challenges by enabling, specific interactions between molecules on the surface of the nanoparticle and molecules in the diseased tissue, while minimizing off-target interactions toward non-diseased tissues.