Sentence examples for off-target effect from inspiring English sources

"The two trials together seem to tell us that torcetrapib had an off-target effect," Dr. Nissen said, referring to a negative side effect.

No off-target effect including (major) metabolites.

The MABEL approach should consider additional points: No off-target effect including (major) metabolites.

The mitochondrial serine protease HtrA2/Omi was identified as being responsible for this off-target effect.

And the sense strand off-target effect of VII decreased remarkably.

The effects of intensive LDL-C lowering on neurocognition might be attributed to an off-target effect.

The possible reasons for this are an off-target effect or a problem with specific sequence of RNAi.

That's an off-target effect, Zhang explains, that is secondary to the drugs' ability to lower blood sugar.

However, the clinical development of such otherwise well tolerated compounds has been spoiled by their hepatic liability that has been considered an off-target effect.

We carefully examined the top 3 potential off-target sites and found no unwanted off-target effect (Figs. 2D and S3A).

In particular, off-target effect of CRISPR/Cas9 should be investigated thoroughly before any clinical application (Baltimore et al., 2015; Cyranoski, 2015; Lanphier et al., 2015).