Sentence examples for off-target benefits from inspiring English sources
Reducing elevated calpain activity in HD mice also had beneficial off-target benefits [ 68, 69].
A second approach is to modulate alternate pathways and achieve off-target benefits.
In addition, many of the conventional therapeutics have off-target effects that mitigate the benefits provided.
Galactosylated nanocarriers have recently emerged as viable and versatile tools to deliver drugs at an optimal rate specifically to their target tissues or cells, thus maximizing their therapeutic benefits while circumventing off-target effects.
FUTURE DIRECTIONS: Pharmacologic interventions for hypertensive patients will need to exploit this robust bidirectional relationship between ROS generation and immune activation in cardiovascular control organs to maximize therapeutic benefit, while limiting off-target side effects.
Such pathways also have the added benefit of reduced off-target effects due to their inherent lineage restriction.
It is possible that, in each of the three cases a different off-target effect may have neutralised an underlying benefit of the drug.
Mutated Cas9n nickases have also been shown to effectively facilitate the creation of both knock-in and knock out mouse models with the added benefit of reduced levels of off-target effects [ 67].
The FDR does not appear to benefit and remains comparable between WGS and off-target results (5.5% for cnvHiTSeq and 11.1% for CNVnator versus 5% for cnvOffSeq).
In this study, we reported that the off-target activity of lapatinib in augmenting NF-κB activity may enhance the therapeutic benefits of bortezomib for TNBC patients.
In addition to therapeutic and diagnostic functionalities, peptides have potential benefits such as biocompatibility, ease to synthesize, smaller size, by-passing off-target side effects, and achieving the beneficial effects with lower-administered dosages.
