Sentence examples for off-target affects from inspiring English sources

This modification has provided an additional method for reducing off-target affects through the fusion of the FokI catalytic domain to dCas9 (fCas9) [ 54, 55].

Therefore, the Wood study and our study work together to underscore the need to design better QSIs that do not suffer from off-target affects that can select for resistance.

Ultimately, some of the drug will end up off-target, affecting non-cancerous cells.

It is possible that there were other common focus genes in common between MCF7 and MCF10A that were masked by off target affects of the S-siRNA control.

While binding of drugs to their primary targets or off-targets affected pathways, perturbed pathways can cause phenotypic effects in human biological system.

However, the QSIs in P. aeruginosa that are free of off-target growth affects do not sufficiently inhibit QS.

However with BMPPB-32, there is no significant change in the CRFs in the dLRRK − knockout (Fig.  9A and Biv), suggesting this compound has no major off-target effects affecting the SSVEP.

To determine the extent to which off-target transcripts affect the intensities of matching probes, we carry out a detailed mapping between each 25-bp probe on Affymetrix exon arrays and off-target transcripts using the SeqMap algorithm (see Section 2).

Plasminogen activator inhibitor-1 protein levels were also moderately reduced in scrambled control compared with non-transfected cells, which could be attributed to RNAi pathway saturation and/or secondary off-target effects affecting PAI-1 pregulatoryulatory factors, as previously described for other cases (Grimson et al, 2007; Khan et al, 2009).

Having identified the TGF-β signature (on-target signature) as well as the affected pathways by GSEA, we next screened the seven NCEs for their specific off-target effects and affected pathways.

In this article, we describe how matches between short oligonucleotide probes and off-target transcripts can affect probe intensities.