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To quantify how selectively the individual patches respond to airflow on and off, we calculated an On-Off Selectivity Index (OSI) for each patch (see Materials and Methods).
Because of this, when calculating the On-off Selectivity Index (OSI), these negative values were set to zero to keep the OSI in the range of –1 to 1.
Additionally, PF-04957325 shows no activity in an off target selectivity panel screened at single dose at 10 µM concentrations.
sdfSelectivityCalculator computes off-target selectivity.
sdfSelectivityCalculator computes off-target selectivity 6.
It is well known that those composite membranes suffer from a trade-off between selectivity and permeability.
This paper provides a possible solution to break the trade-off between selectivity and ion conductivity of porous membranes.
Gas separation by metal-organic framework (MOF) membranes are still unsatisfactory due partly to unsatisfied separation characteristics caused by the trade-off between selectivity and permeability.
The addition of up to 30% DVB led to an increase in the binding capacity with very little trade-off in selectivity.
A fused tricyclic methyl, hydroxyl geminally substituted pyrrolizinone (compound 20) had excellent functional IP (<2% SP remaining), hNK1 binding affinity, off-target selectivity, pharmacokinetic profile and in vivo activity.
Before proceeding we did, however, assess "off-target" selectivity.
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