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It has been field-tested for educational effectiveness and feasibility of wide implementation.
One of the biggest concerns of wide implementation of lung cancer screening by CT, is radiation risk and radiation-induced cancer.
However, a randomised controlled trial in an ordinary primary care context is difficult to perform without losing the main aim of wide implementation.
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In view of the large numbers of smokers admitted to secondary care, the public health impact of wider implementation of this approach is potentially massive.
There has been a switch in the type of presentation of HCC in developed countries, with a clear increase of tumors <2 cm in diameter as a result of the wide implementation of surveillance programs.
As recently suggested however [ 29], the situation might change since we foresee a larger share of HCC patients diagnosed in this stage as a result of the wide implementation of surveillance programs, at least in the western world.
Second, present case studies to introduce novel technologies and approaches that have the potential of facilitating wide implementation of QbD.
This study forms part of a service evaluation of a system wide implementation of a patient initiated review appointment system which we have called Direct Access (DA).
Berg et al. (ACRIN study) [ 32] noted that lack of uniformity and shortage of qualified personnel limit wide implementation of hand-held imaging.
However, all these methods have some shortcomings, such as complex methodology, time-consuming steps, and expensive instruments, all of which discourage wide implementation.
The incidence of RCC is increasing, most likely due to the wide implementation of imaging modalities, such as ultrasonography and CT-scanning [ 4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com