Moreover, cancer represents a field in which new technologies, including drugs, evolve quickly, and for which indications of current technologies also expand rapidly, raising several relevant HTA questions.
Drugs granted orphan drug designation at the time of original approval were subsequently approved for 77 supplemental indications, 40 (52%) of which were indications not related to rare diseases.
In the presence of CNS-1 tumour, endothelial cells undergo hyperplasia and display a pseudo-palisading pattern accompanying necrosis (Kerbel, 2008), both of which are indications of increased angiogenesis mimicking human GBM (Beranek, 2002).
However, after the onset of hind-limb dysfunction, βLKB1KO mice displayed significantly reduced mobility as characterized by an unwillingness to move and by crouching, both of which are indications of possible trauma.
(I) The descent pattern of the fetus is one of the indications, which indicates how well the labor progresses.
Should reliability be below this cut-off but with ppos (or pneg), arbitrarily, >60%, this strategy can still be used by randomising only those patients of which the indication was agreed upon by two manual therapists.
Both the nuclear communities and the "Daocratic" realm as a whole were bound together by a ritual cycle, of which only fragmentary indications remain.
It remains unclear whether neuropsychological symptoms and cardiovascular disease, neither of which are currently indications for recommending parathyroidectomy (PTX), are part of the modern phenotype of PHPT.
During the 11th century more and more churches were constructed in the Romanesque style, the massive forms of which are another indication of this sculptural instinct.
Moreover, although therapeutic gain was a low probability, early indications of activity were indeed observed with many agents, some of which led to eventual indications for approval.
