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We showed up-regulation of EGR1 following cisplatin, methotrexate, etoposide, or doxorubicin treatment, each of which exerts cytotoxic effects by different pharmacological mechanisms.
Humans have two separable and parallel control networks, i.e., fronto-parietal and cingulo-opercular networks, each of which exerts top-down control, though with different properties and over different temporal scales [ 30, 31].
Despite the potent effects of TZDs and GLP-1 agonists on β-cells, the two most commonly prescribed drugs in the U.S. and worldwide are sulfonylureas and metformin, neither of which exerts any β-cell protective effect.
However, if these exposures have low variability among the study cohort, a disease that had previously been believed to arise from many small genetic effects might actually be caused by only a few genes, each of which exerts a relatively large effect.
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We all have our religions, all of which exert a special pull — and draw special fervor — when apprehension runs high and confusion deep, as they do now.
I certainly would not have tried to get a glimpse by visiting his home at Alnwick Castle, the monstrous requirements of which exert a malign influence on the town and countryside around it.
Unlike AT&T and Microsoft, both of which exerted a strong technological "lock in" over their customers, Google operates in a more open market that is easier for competitors to contest.
Meanwhile, the Islamist-secularist polarisation of the public sphere resulted in so many seductive but unproductive debates about Tunisia's national identity, the future of Islam and the Arabic language, all of which exerted an increasing pressure on religious, linguistic, racial and sexual minorities.
ABC transporters comprise various efflux proteins, some of which exert abnormal responses to exogenous compounds due to the presence of polymorphs.
In surface-water dominated hard rock regions, modern ground and surface water monitoring programmes often have very high resolution chemical, meteorological and hydrological observations but lack an equivalent emphasis on the subsurface environment, the properties of which exert a strong control on flow pathways and interactions with surface waters.
These are implemented by a cellular network that connects thousands of molecules, many of which exert a regulatory role in a multiplicity of biological contexts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com