Sentence examples for of which accumulation from inspiring English sources

Peptide of 36 43 amino acids, generated by the sequential proteolytic cleavage of amyloid precursor protein, of which accumulation causes amyloid plaques in AD.

The inhibitor of the cyclin E- (cyclin-dependent kinase) (CDK2) p27KIP1, of which accumulation is observed in response to antiproliferative signals, does not appear to be involved in the response of MM cells to γ-radiation.

Temporal ordering is a feature of cascade theories of ageing in which accumulation of deficits occur in a general sequence, potentially leading to an acceleration of decline once a threshold is reached.

Situations encompassed would include aseptic loosening of prosthetic implants, in which accumulation of metal ions such as Co2+ has been shown to enhance osteolysis (32).

The exact mechanism by which accumulation of L-2-hydroxyglutaric acid causes brain injury is still unknown.

Indeed, in leaves two GS2 spots were identified of which the accumulation levels were differently related to the enzymatic activity.

Concordantly, we detected coimmunoprecipitation between Noxa and Mcl-1 in JVM-2 and Granta 519 cells, both of which showed accumulation of Mcl-1 induced by GUT-70.

The probes of detecting liver fibrosis ought to have the capability of specifically targeting and binding ECM, of which excessive accumulation can result in fibrosis.

Note that these experiments were performed in the absence of phosphodiesterase inhibitor, as a result of which cAMP accumulation is modest.

Among the three identified GS2 forms, the GS2b is the only one of which the accumulation level was significantly increased in plants exposed to NO3−.

19, 20 These include thinning of the endothelium, loss of mitochondria, and thickening of the basement membranes, the latter of which increase the accumulation of focal Aβ peptides.