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Thus, the problem of unknown conformations hinders immunogen design.
Consequently, we have a dilemma of unknown conformations that seriously militates against successful immunogen design.
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However, in the more common case of unknown intermediate conformations a computational method can provide accurate models more quickly.
On the one hand, unknown conformations confound vaccine design against MPER.
Apart from such parameters as low accessibility and unknown conformations, the host tolerance mechanism also influences MPER-specific neutralization responses.
In the case of unknown loop conformation, predicting an unrealistic collapsed loop bears less risk of large GDT_TS loss than predicting an extended (and locally correct) conformation that may deviate further from the target if overall orientation is wrong.
KNtp with an unknown conformation in Mg-ADP state is outlined by dashed lines.
For example, when studying a protein of unknown structure or conformation, one could rapidly determine if some observed bimane quenching in an experiment is due to Trp or Tyr by simply relabeling the same protein with BODIPY 507/545.
However, later research found that Godolphin was a chestnut Arabian of ordinary conformation and no special worth, while Gallipoly was a gray saddle horse of unknown breeding.
It had photographs of unknown….
6. Flagpoles of unknown countries.
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