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Issues of trial design and regulatory approval must also be worked through in advance, so testing is not delayed when epidemics begin.
Instead, a description of the process by which new drugs are tested in clinical trials is provided to illustrate some general principles of trial design.
The reason is one of trial design and statistical declarations.
The gold standard of trial design is the double-blind, placebo-controlled, randomized trial.
The interpretation of clinical trial results requires an understanding of trial design.
The tool will prove particularly useful when implemented in the process of trial design.
This article highlights the scientific aspects of trial design for this pivotal clinical trial.
To understand the structure and pitfalls of trial design and conduction has to be part of modern medical education.
Screening symptoms for their severity prior to trial entry may be an important element of trial design.
In conclusion, analysis of the methodology showed several aspects of trial design that can be improved in future studies.
RCTs are major undertakings and the intricacies of trial design, operations, and management are generally underappreciated by the typical researcher.
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