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Since resveratrol enhances the therapeutic potential of TRAIL by inducing apoptosis in vivo, we sought to examine the molecular mechanisms by which resveratrol enhances the antitumor activity of TRAIL in PC-3 xenografts.
I tried to avoid wading a scummy patch of trail by going up and over but fell coming down and got heaved out by a cheerful French couple.
These data suggest that resveratrol can enhance the apoptosis-inducing potential of TRAIL by activating FKHRL1 and its target genes.
Similar to our findings showing induction of TRAIL by NFAT, activation of NFAT isoforms, including NFATc1, up-regulated FasL expression [34], [35] and TNFα expression [36] in several cell types.
We have recently demonstrated that resveratol enhances therapeutic potential of TRAIL by upregulating death receptors (TRAIL/DR4 and TRAIL-R2/DR5) and also engaging mitochondrial pathway of apoptosis [2], [3].
Moreover, intra-articular over-expression of TRAIL by viral gene transfer exerted a comparable effect in a rabbit arthritis model.
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