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Biologically active forms of TRAIL include membrane-bound TRAIL and soluble TRAIL [4], [28], [73].
Analysis of TRAIL receptor surface expression revealed that TRAIL-R2 was expressed in all studied cell lines in contrast to little expression of TRAIL-R1.
In both studies, RASFs showed constitutive expression of TRAIL receptor-2 (DR5) as the main mediator of TRAIL-induced stimulation.
This hampers efficacy of TRAIL-based therapies and to date, the therapeutic benefit of TRAIL in clinical trials is indeed rather limited.
The antiangiogenic function of TRAIL might represent a common link between the apparently distinct roles of TRAIL in cancer and in endothelial cell biology.
Assessment of TRAIL-receptor expression patterns may have therapeutic implications for the use of TRAIL receptor agonists in HCC therapy.
Different strategies of TRAIL sensitization and a dependency on Bax have been reported, but common principles of TRAIL resistance and the way of Bax activation remained poorly understood.
We show that the constitutive localization of TRAIL receptor DR4 into lipid rafts could represent a critical variable causing anticancer activity of TRAIL.
Oakland has completed 24 of its 38 miles of trail.
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(D) FESEM image of TRAIL- and endostatin-loaded TPGS-b- PCL-ran-PGA)/PEI nanoparTPGS-b- PCL-ran-PGA
In addition, the level of TRAIL-R2 expression was much higher than that of TRAIL-R1.
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