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The ICC quantifies the proportion of total outcome variance that is due to inter-individual variation.
Fewer numbers of total outcome events in studies was strongly correlated with increasing magnitude of the treatment effect (Pearson's R = -0.70, p < 0.01).
Our review suggests that statistically significant results in orthopaedic trials have the following implications-1) On average large risk reductions are reported 2) Large treatment effects (>50% relative risk reduction) are correlated with few number of total outcome events.
* Represented as the mean relative risk reduction across studies Our review of trials with statistically significant findings in orthopaedic trauma suggests the following: 1) trials have small sample sizes 2) average treatment effects are large and 3) large treatment effects (>50% relative risk reduction) correlated with fewer number of total outcome events.
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Bernoulli shows through mathematical induction that given a the number of favorable outcomes in each event, b the number of total outcomes in each event, d the desired number of successful outcomes, and e the number of events, the probability of at least d successes is P=\sum_{i=0}^{e-d}\binom{e}{d+i}\left(\frac{a}{b}\right)^{a+v}\left(\frac{b-a}{b}\right)^{e-d-i}.
Using the BRSS, rather than the much more exhaustive HSSS, to retrieve RCTs in journal articles for Cochrane reviews, affected only a very small percentage of total outcomes of a few reviews, and made no important difference to the conclusions of these reviews.
Break the odds into two separate events, plus the number of total outcomes.
Another way to think of this is as the Number of total outcomes minus the number of favorable outcomes.
This makes it necessary to focus on work-related stressors as a part of the total outcome spectrum in evaluations of the psychiatric health services [ 15].
On average, trials recruited 63% of the planned sample and stopped after when a median of 66 total outcome events (experimental + control).
Of the total outcome payment, 80% has been assigned to learning and 20% to enrolment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com