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Completed questionnaires were received from 2547 male controls, representing 59.6%% of those ascertained and 64.0 % of those contacted.
Completed questionnaires were received from 2362 cases, representing 78.4% of cases who were sent questionnaires and 69.7% of those ascertained.
In all, 2,547 male controls returned completed questionnaires, representing 64% of those contacted and 60% of those ascertained.
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In total, 2492 women completed and returned the questionnaire, representing 71.3% of those contacted and 64.8% of these ascertained.
The majority of studies used clinically ascertained samples of individuals with TS, which may differ substantially in disease severity than those ascertained through population based means.
However, none of those studies ascertained the impact of BMI on insulin dose requirements.
HLA genotypes of the members of the ascertained nuclear families.
Although the reference heterozygosities were for the CEPH population which has a European ancestry, we tried not to make the choice of loci totally random since regional heterozygosities tend to follow similar relative order to those of loci ascertained in a geographically diverse panel [25].
A limitation of this study is the use of a set of ascertained SNP to map QTL.
This disproportionality was independent of the density of ascertained genes on these chromosomes.
At the first 2-year follow-up, participants were asked if they had ever been diagnosed by a physician with diabetes, and date of diagnosis was ascertained for those who gave a positive answer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com