Sentence examples for of this docking from inspiring English sources
Results of this docking study suggested that indoles bearing the basic tetrahydronaphthyridine group at position 4 can easily adopt the correct binding conformation and should be as potent as our current 5-substituted indole leads 3 and 4.
We speculate that the IGF-I-activated IGF-I receptor, in response to E2, directly or indirectly modifies insulin receptor substrate-2, probably through phosphorylation, leading to ubiquitination and subsequent degradation of this docking protein by the proteasome.
The main aim of this docking study was to identify the active site residues by determining the bound conformation of glutathione/bradykinin in the active site of OppA and correlating the result with mutational analysis.
As a result of this docking analysis, we conclude that the most energetically favorable binding site is the Glu275 residue.
Importantly, inhibition of the PI3K/AKT pathway or mutation of S159 resulted in increased tyrosine phosphorylation of this docking protein, and the Gab2S159A mutant displayed transforming properties in fibroblasts.
To examine whether the integrity of this docking motif is required for Rab2A to bind to Erk, we substituted the known critical residues KR (mut1) or LXI (mut2) or both residues (mut1/2) with Ala residues.
He added: "The village has concerns about the length of this dock.
If you dig the design of this dock, they cost $45 for the iPhone version and $70 for the iPhone and Apple Watch version.
A number of the proteins in this docking complex have been identified, including two that have been referred to as the 'yin and yang' of vesicle fusion: synaptotagmin, which promotes fusion, and Rab3, which limits it.
Given the growing importance of Gab2 in several tumour entities we expect that our results will help to understand the complex regulation of Gab2 and how this docking protein can contribute to malignancy.
This docking study of the 40S ribosomal S9 protein showed that out of 10 docked conformations, the 3rd conformation was the best because it has comparatively lower binding energy as well as hydrogen bonding.
