Sentence examples for of this cleavage from inspiring English sources

Because of this cleavage in national leadership, the bulk of the activity in the 1840s and '50s was carried on by state and local societies.

The goal of this project is to study in vitro the caspase-3 cleavage site of hTau protein and to examine the kinetics of this cleavage following Ser422 phosphorylation and treatment with caspase-3 inhibitors.

The formation of Alzheimer's Aβ peptide is initiated when the amyloid precursor protein (APP) is cleaved by the enzyme β-secretase (BACE1); inhibition of this cleavage has been proposed as a means of treating Alzheimer's disease.

The mutation leading to the loss of this cleavage site actually stops APC from effectively inactivating both Factor Va and Factor VIIIa.

The biological significance of this cleavage is therefore unknown.

The in vivo consequences and significance of this cleavage on Drosophila Notch signaling remain unclear and contradictory.

This means that the specific cleavage of the LTR-LTR junction is primarily mediated by a water molecule and the catalytic mechanism of IN for this cleavage is similar to the well-known mechanism for 3'-processing.

Furthermore, the oligomeric state of IN responsible for this cleavage differed from that involved in the 3'-processing reaction.

To investigate whether the neurite growth-promoting action of the murine proNGF that had an R-to-G substitution at amino acid 104 used above is a peculiarity of this cleavage-resistant form of proNGF, we examined the effects of a different cleavage-resistant form of proNGF and the effects of native proNGF on neurite growth.

It may well be that several enzymes are capable of catalysing this cleavage event, precluding the use of inhibitors to identify the specific protease(s) involved.

To our knowledge, this is the first observation under experimental conditions of a cleavage at this site, although the precise role for this cleavage remains unclear.