Sentence examples for of this checkpoint from inspiring English sources

Many important members of this checkpoint have been identified, including the genes Bub1, Bub3, Mad1l1, Mad2l1, Mxd3 and Mps1 (ref. 10).

Our investigations also revealed that central B-cell tolerance defects are primary to many autoimmune diseases including rheumatoid arthritis, type 1 diabetes and systemic lupus erythematosus and can result from genetic polymorphisms such as the R620W PTPN22 risk allele associated with all these diseases and that was reported to alter BCR signaling important for the regulation of this checkpoint.

To investigate the status of the mitotic spindle assembly checkpoint (SAC) we initially studied the expression level of some protein involved in the regulation of this checkpoint.

The predicted network reproduces many of the known features of the SAC and provides new insights about the function of this checkpoint.

They also show that E-cadherin and Cnn (and possibly Apc1) are essential components of this checkpoint, while Apc2 is not.

The PTX-induced endoreduplication is associated in Myc overexpressing cells with a reduced expression of MAD2, essential component of the molecular core of the spindle assembly checkpoint (SAC), indicating an impairment of this checkpoint.

This suggests that the inhibitory effect of TGFBI on this checkpoint may be related to these two molecules.

The involvement of DDB2 at this checkpoint of the cell cycle correlates with the fact that it is well expressed in dividing and undamaged normal cells in the mid-G1 phase and peaks at the G1/S boundary, before dropping significantly in the S phase [12].

Tens of thousands of vehicles pass through this checkpoint every day as they enter Kabul from the eastern provinces of Nangarhar, Logar, Kunar, Laghman and as far as Pakistan.

These studies showed that SW620 cells undergo synergistic cell death after spindle checkpoint activation followed by cisplatin treatment, suggesting a role of Chk1 in this checkpoint, very likely dependent on BubR1 protein.

The sudden surge of traffic at this checkpoint comes as the Nafusah rebels try to consolidate their hold on towns in the region in battles on at least three fronts.