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Although both prodrugs have recently been shown to kill Mycobacterium tuberculosis through the inhibition of the dehydration step of the type II fatty acid synthase pathway, their detailed mechanism of inhibition, the precise number of enzymes involved in their activation, and the nature of their activated forms remained unknown.
Western blot analysis showed enhanced processing of these caspases, with the appearance of their activated enzymes 8 h after DEX treatment.
Western blot analysis showed enhanced processing of caspase-1, -7, -11, and -12, with the appearance of their activated enzymes 24 h after TNF-α treatment.
An edibles company touted a large jar of their activated chocolates, but when I attempted to eat one, their representative stopped me.
We used the ability of the BCF-CM to promote breast cancer motility in a scratch wound assay as an indicator of their activated phenotype.
In situ zymography and immunohistology showed association of enzymatically inactive prodomain-containing proMMP-2 and proMMP-9 but not of their activated forms to fibrillar collagen structures, which are not substrates of these gelatinases.
Similar(49)
After their activation, PXR and CAR coordinately induce a machinery of genes responsible for detoxification and elimination of their activating toxic ligands.
Transition between the different phases and subsequent progression through the mitotic cycle is driven by a group of protein kinases whose activity is central to this process, the cyclin-dependent kinase (CDKs), and requires the binding of their activating partners cyclins, whose levels of expression varies throughout the cycle.
In mammalian cells, cell cycle progression is governed by distinct cyclin-dependent kinases (cdks) whose activities are regulated by binding of their activating cyclin subunits and through negative regulation by inhibitor proteins such as p21.
After triggering of their activating receptors, NK cells degranulate and release the cytolytic factors perforin and granzymes.
All are potentially sensitive to inhibition of their activating proteases by host or pharmacological protease inhibitors.
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CEO of Professional Science Editing for Scientists @ prosciediting.com