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In this case, the values of the two first thresholds of the common new set can be those of the reference threshold set τ 1 a, τ 2 a, τ 3 a, but the third is given by τ 3 a * = σ τ 3 b - τ 1 b - τ 1 a with σ = τ 2 a - τ 1 a / τ 2 b - τ 1 b.
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We have defined observed apnea by a positive response to the question, "Has someone said to you that you stop breathing during your sleep?" The sleep questionnaire (11), as shown in the online appendix, included the Epworth Sleepiness Scale, which provides a measure of daytime sleepiness, that we study with the reference threshold of 10 or higher, which was derived in a general population (12).
Two intra-assay coefficients of variation of the assay were used as the reference threshold for the pulse detection.
Two intraassay coefficients of variation of the assay were used as the reference threshold for the pulse detection.
Using the reference threshold of protein-ligand interaction (correlation coefficient: 0.39), three major clusters can be identified in Figure 3b, clusters c, d and e.
The reference threshold of atom-pair (Tanimoto coefficient: 0.55 in Fig. 2) was calculated via 7 classes of structures showing the complement between atom-pair descriptor and protein-ligand interaction descriptor.
Interestingly, the inferred average LD r value is 0.6 at 0 cM inter-marker distance, i.e. at the maximum resolution provided by the linkage studies, is far below the reference threshold of r = 0.8 currently accepted as the r value to select representative SNPs for GWAS (tagSNPs, [ 54]) in those species where this resource is available.
The methodology is based on the computation of a reference threshold from the residue generated between the states of the system and the filter estimates such that when the residue takes values higher than this reference threshold the uncertain system is considered in fault.
Firstly, the previous systematic review pooled all studies irrespective of the reference standard threshold used, whereas the present study sought to determine the importance of individual symptoms and signs at different reference standard thresholds.
Table 7 Performances obtained using Euclidean distance by combining the two methodologies with the two sets of reference (threshold with α=2) ComplOverlap Eucl + All Output×G T 1 70 83 Output×G T 2 77 83.
Table 6 Performances obtained using Euclidean distance by combining the two methodologies with the two sets of reference (threshold with α=1) ComplOverlap Eucl + All Output×G T 1 50 43 Output×G T 2 43 47. Figure 14 shows the results from using thresholds with α=2.
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