Christl Donnelly is professor of statistical epidemiology at Imperial College London and was a key member of the randomised badger culling trial (RBCT).
It has also served as a lesson in collaboration, because it has been necessary to consider the needs of both the programme, and of the randomised trial.
Matura, S. et al. Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial.
Sihvonen, R. et al. Arthroscopic partial meniscectomy versus placebo surgery for a degenerative meniscus tear: a 2-year follow-up of the randomised controlled trial.
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
The estimates vary according to the methodology of the randomised trials, and the design of the observational studies.
Both are done up using the now-mandatory light-industrial tropes of the randomised, reclaimed and upcycled.
But not everyone's convinced by this reworking of the Randomised Badger Culling Trial with the benefit of hindsight.
The design of the research of the randomised block type contained three separated blocks (replicates).
Fig. 3 Global Change in Weekly Attack Frequency at the End of the Randomised Phase (mITT Populationa).
In the nVNS + SoC group, 8% of patients were attack free for the duration of the randomised phase, and no patients receiving SoC alone had this result.
