Moreover, these efforts are necessary not just to mitigate the risks of the profound shifts underway but also to capitalize on the opportunities presented by the Fourth Industrial Revolution.
From their days at Wellesley, where they attended Wednesday teas and fought to end parietal hours and curfews, to their pioneering careers in law, academia and science, the 400 members of that Class of 1969 have been marked by the profound shift in women's roles that accompanied their coming of age.
It gradually dawned on me that I was going to have to figure out for myself how to translate the profound shift of perspective I was experiencing into a form that would make deep sense to the world I was living and working in.
That's really the profound shift in Office 365".
Proponents of the change say Wall Street's wary embrace of the activity may signal the beginning of a profound shift in the way investment banks are structured, with everyone but the top deal makers, client representatives and the bank management permanently relocated to cheaper locales like India, the Philippines and Eastern Europe.
The Anthropocene is up there with Copernicus's heliocentricity or Darwin's theory of evolution as one of the most profound shifts in worldview that has emerged from scientific endeavour.
The transition to a professional military had begun during the late Republic, and was one of the many profound shifts away from republicanism, under which an army of conscripts had exercised their responsibilities as citizens in defending the homeland in a campaign against a specific threat.
In this new paradigm - one that is a consequence of the profound demographic shift of population aging - fiscal sustainability and economic growth are only possible if we also shift our expectations of aging to engagement, activity, work and contribution.
One of the most profound shifts in our view of and interaction with children takes place when we realize -- and I mean, truly get -- that they make sense.
For all the speculation leading up to President Obama's second State of the Union address, the most profound shift in the speech turned out not to be a move from left to center, as some had predicted, but rather a move away from legislative priorities in favor of telling a broader American story.
