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Because of the profound modifications within the MSC population, the comparison of MSC gene expression before and after challenge should be interpreted with caution as they are the result of mixed molecular and cellular effects.
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Impact on gene expression: no doubt exists about the profound modifications of gene expression by exposure to simulated or real microgravity.
Twenty-three oft of 42 criteria were significantly associated with Y. pestis infection, reflecting the profound modification induced in the DLN by this bacterium.
Sexuality is one of the aspects that undergoes the most profound modifications.
The present osteoblastic consequences of MSU ingestion are profound modifications of their functional phenotype that, in the context of bone tissues in gout, validate the pathologic findings of MSU microcrystals remaining encrusted in bone.
Since the integration, profound modifications have occurred.
In addition, the pattern of ecosystem demands shows a levelling of rural urban gradients, reflecting profound modifications of traditional rural urban relationships.
Such alteration of hematopoiesis is constantly associated with profound modifications of the bone marrow and spleen stroma as demonstrated by the presence of myelofibrosis, osteosclerosis and neoangiogenesis in PMF patients [ 5].
Nevertheless, in two closely related species, which have shifted to another functional group of pollinators (i.e. bees instead of saprophilous flies and beetles), the design of the pollination trap showed more profound modifications.
After the colonies passed to the British crown, the old law underwent profound modifications, partly because of changed social and economic conditions and partly because of the incursion of rules and institutions derived from English common law.
We have demonstrated for the first time that MVT-treatment is associated with profound modifications of the cardiac transcriptome in both healthy and diabetic conditions.
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