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Sensitivity, measuring the proportion of the known disease-associated genes that were correctly prioritised, was defined as TP/ TP+FN) and precision, measuring the proportion of the prioritised genes that were known disease-associated genes, was defined as TP/ TP+FP).
Time constraints did not allow a complete hazard assessment of the prioritised substances, including the setting of toxicological reference values to be used for risk assessment.
Finally, using a 'fine radar', detailed problem analyses of the prioritised topics were made to present concrete suggestions for funding by the BMBF (pre-projects).
In our group, we have been using TargetMine for analysing a diverse array of experimental data and we have verified experimentally that some of the prioritised genes have been associated with the disease of interest [54].
A total of 1079 SNPs were selected from the Affymetrix data as associated with the prioritised candidate genes, falling either within the genes or within 100 000 bp either upstream or downstream of the gene (Supplementary Data File S2) (the SCNN1b gene was not included in this analysis as it was not one of the prioritised genes).
Indeed, two of the prioritised services did not receive funding, indicating that the criteria were inadequate.
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No additional contribution from exposure via inhalation of vapour is expected for the prioritised metals, given their very low vapour pressure.
In the absence of headspace analysis data for the prioritised substances, exposure to vapours was not included for the inhalation route.
If CMAC does not allocate sufficient resources to attend to the prioritised needs of the community, the community will lose confidence in the project.
The objective of these meetings was to encourage women to identify local and low cost ways of tackling the prioritised problems using local resources.
Ten of the highest prioritised items were selected for this study.
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