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The efficacy of the present schedule in terms of responses obtained compares favourably to previous regimens (Table 3).
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It is a slip of about 12 months on the present schedule.
However, due to the unexplored nature of bovine primer pheromones the present schedule was chosen to avoid a possible spillover effect from periods of treatment to periods of control and also to avoid contamination when handling the substances simultaneously.
In conclusion, the present schedule of panobinostat in combination with IM is tolerated in heavily pretreated patients with metastatic GIST but future studies should use a 2 week on or 1 week off schedule to improve the tolerability.
To the best of the authors' knowledge, this is one of the properties of all the present scheduling schemes.
Furthermore, real-time performance of the presented scheduling scheme is researched by a constraints model and the corresponding simulation result shows a good performance, where the overtime ratio is 10.3% under an extremely bad condition.
The application of the results of the present study to schedule inspections with optimal time interval is highlighted.
Salient features of the presented joint scheduling policy are that: (i) it is self-adaptive; (ii) it is able to provide hard (i.e., deterministic) QoS guarantees, in terms of hard limited playout delay and playout rate-jitter; and (iii) it explicitly accounts for the performance interaction of the protocols implemented at all layers of the considered stack.
The MTD of BM in the present dose schedule was 180 mg m−2 on day 1+2.
This was done for all the selected masses of gaseous species using the present scan schedule as a trigger.
This has to be done subject to a set of relatively common constraints related to the scheduling of the present jobs and resources.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com