Sentence examples for of the ppis from inspiring English sources

In contrast, there are only a limited number of drug target PPIs deposited in databases, TIMBAL (7) and 2P2IDB (8), despite the biological importance of the PPIs.

Clustering of the PPIs into three groups was performed using the K-mean method [26].

This is because the number of the NPPIs is orderly larger than the number of the PPIs.

For PPI-Nem, three of the PPIs had domains that were considered druggable (Table 2 and Table S1 and S4).

We show that in addition, some of the PPIs that we predicted but are not yet recorded in any database represent indirect protein interactions and have biological relevance.

A text mining score from STRING could be obtained for 30% of the PPIs, in line with the co-occurrence based approach used to create STRING.

Herein, we describe the intricacies of the biological theory, datasets, and features required for modern protein-protein interaction site (PPIS) prediction, and present an integrative analysis of the state-of-the-art algorithms and their performance.

Thus, the PPIS colony displays very low levels of genetic polymorphism.

Deciphering structural and energetic determinants of PPIs is a prerequisite to understanding the PPIs-mediated functions in living cells.

On the same line, it is conceivable that the PPIs-catalyzed interconversion of cis into trans peptidyl-prolyl bonds could facilitate dislocation of ERAD substrates across the ER membrane by eliminating turns in the polypeptide secondary structure [9].

We obtained information on chemical class by linking the databases of the U.S. EPA PPIS and the Pesticide Action Network PANN; an organization that compiles information on pesticide class, toxicity, and health effects from official sources) (PAN 2011), using the U.S. EPA pesticide chemical codes (PC codes) that are unique to each active ingredient.