Scores are the total number of correct responses on the learning trials (CV LT1), on the two recall conditions (CV LT2, CV LT3) and on recognition (CV LT4).
We next re-analyzed and re-plotted all our data that depended on the learning trials of mice and found that all the conclusions in our original submission remain un-changed.
An analysis of the rate of forgetting, including the learning trial 5 and the delayed free recall score from CVLT as between subject factors, showed no statistically significant APOE group difference.
After completion of the learning trials, the platform was removed from the pool.
The list is repeated three times, generating a sum of the learning trials (0 36 points).
According to Lezak et al. [ 29] we give detailed information about the total score of the learning trials, thought to reflect in part encoding, delayed verbal free recall, thought to reflect retrieval of retained information from episodic memory, and recognition.
However, for the group of trials after the learning trial, the distribution was much closer to a uniform distribution (χ = 20.53, p=0.015, Figure 3I).
In the study recommended by the reviewers (Wirth, Yanike, et al., 2003), and a subsequent article with many of the same authors (Smith, Frank, et al., 2004), we found an analysis algorithm that allowed us to address the problem of rigorously identifying the learning trial for each mouse.
The difference between numbers of words remembered in the learning trial versus the delayed recall was obtained as an estimation of forgetting.
For those subjects that did not reach the learning criterion by the end of testing, we imputed the learning trial to be the earliest trial on which performance exceeded chance level and remained above chance over all remaining observed trials, or if even this relaxed criterion was not satisfied, we used 1+[total number of trials completed].
