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Fig. 1 NDDCs by count of target joints (N = 1227).
Prevention and management of target joints should be an important consideration of managing haemophilia patients.
The number of target joints are positively correlated with NDDCs: individuals with one target joint reported mean NDDCs of EUR 3468 (SD 5595; n = 332) (Fig. 1); this increased to EUR 5585 (SD 7980; n = 242) for patients with two target joints; for those with three target joints mean NDDCs were EUR 7470 (SD 9396; n = 70).
Presence of target joints in the CHESS patient group is significantly higher among those receiving prophylaxis; whilst initially counterintuitive, it points to a large number of patients moving away from on-demand regimens due to poor bleed control and joint damage.
Other important aspects are the method of determination of disease progression and the selection of target joints.
The presence of target joints and synovial hypertrophy, extent of haemophilic arthropathy, physical activity and age may also influence bleeding patterns in patients with haemophilia 14, 15.
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Mean number of target joint surgeries in the affected group was 0.70.
A significant reduction from baseline was observed in assessor evaluation of target joint tenderness at week 12 (P = 0.002) (Table 3).
A significant reduction from baseline was observed in assessor evaluation of target joint swelling at week 12 (P = 0.0005) (Table 3).
The prevalence and 95% confidence interval (CI) of CC (including MCPJ calcification) was calculated at each joint region for any, unilateral, bilateral, and isolated CC (that is, involvement of target joint without involvement of any distant joint).
Other secondary outcomes: Included patient's global assessment, function of the target joints, ESR and serologic markers of inflammation (blood tests), duration of morning stiffness, number of tender and swollen joints, number of analgesic pills, cumulative dose of glucocorticoids, NSAIDs or colchicine and safety [ 13 ].
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Justyna Jupowicz-Kozak
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