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Figure 3 shows the main trends of repositioning highlighting that, among our selected drug portofolio, the repositioning of antihelmintics to antineoplasic agents and of antineoplasic agents to antibacterials of systemic use were the most frequent drug reclassifications.
The hypothesized mechanism of action of local rGH application is to increase endochondoral bone formation in the mandibular condyles without possible side effect of systemic use of rGH.
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Total prescribing of antimicrobials for systemic use ranged from 1.28 – 24.78 DID between practices.
Local treatment was sufficient to deal with these superficial infections and there was no need for systemic use of antibiotics.
In 2 patients, peroperative cultures showed no growth, due to systemic use of antibiotics preoperatively.
This randomized, double-blind, placebo-controlled clinical study aimed at evaluating the effect of the systemic use of an herbal compound (Catuama) on the symptoms of burning mouth syndrome (BMS).
We assessed the clinical impact of the systemic use of antibiotics on postoperative infection in colorectal surgery.
The major disadvantages of the systemic use of non-selective Na channel blockers are cardiotoxicity and CNS sedation and confusion, considered to be produced by NaV1.5 and NaV1.2 channel blocking, respectively.
Our results raise the possibility of an increased risk of bladder cancer from systemic use of glucocorticoids, and a potential role of immune surveillance in bladder cancer aetiology.
We also used a 13-item asthma severity score questionnaire to evaluate four overall components of asthma severity in the asthmatic children, including frequency of current asthma symptoms, use of systemic corticosteroids, use of other medications (besides systemic corticosteroids), and history of hospitalizations and intubations (Eisner et al. 1998).
The results provided the first proof of concept for the systemic use of a pleuromutilin antibiotic in the treatment of SSSIs [ 105].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com